Windows VPS Hosting : dotNetPanel or Virtuzoo (Plesk)?

Plesk also allows for the use of third-party applications which will allow you to configure your Plesk installation to function exactly the way you want it to, right down to which applications are used for specific services that are important to the running of the websites which you are hosting – for example, Plesk uses the MailEnable mail server by default, but you may wish to use the SmarterMail email server and webmail interface so that you are able to make use of the extra features, and SmarterMail is just one of several email servers supported by Plesk.

I will also recommend Plesk because has a good interface and can be used easily even by a new user.

DotNetPanel is free.

Plesk - its good and automated.